Avoiding diaper rash. The best way to avoid diaper rash is to change your baby frequently, especially if the diaper is very full or has stool in it. This ensures their waste does not sit on their skin any longer than necessary. Diaper rash creams, ointments, and powders can be used to prevent or treat diaper rash. Use diaper wipes or water to clean your baby during diaper changes and be aware of any irritation to your baby’s skin. This might mean trying a new type of diaper. Parents should consult their medical provider if a diaper rash seems severe.